Search Results - Biotechnology

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Mitochondrial complex II mutated SDHD cell line
The HEK293ΔSDHD cell line expresses a CRISPR/Cas9 mutated nuclear encoded subunit, SDHD, of mitochondrial complex II (succinate dehydrogenase). This cell line has been shown to significantly alter the function of complex II (CII) of the mitochondrial electron transport chain and displays disruptions to SDHD that mimic clinical presentations of...
Published: 10/11/2021   |   Inventor(s): Aloka Bandara, Joshua Drake, David Brown
Keywords(s):  
Category(s): Biotechnology, Drug Discovery
HEK293ΔNDUFS2 Cell Line
The HEK293ΔNDUFS2 cell line expresses a CRISPR/Cas9 mutated NDUFS2, shown to significantly alter the function of complex I (CI) of the mitochondrial electron transport chain. This NDUFS2 mutant cell line displays disruptions to NDUFS2 that mimic isolated complex I deficiency and can be used as a powerful model of several types of mitochondrial...
Published: 10/11/2021   |   Inventor(s): Aloka Bandara, David Brown
Keywords(s):  
Category(s): Biotechnology, Drug Discovery
3D Printable Multifunctional Fibers
THE CHALLENGE 3D printing has enabled the customized production of many objects and devices, but that technology currently only creates passive units. THE SOLUTION Researchers at Virginia Tech have developed a coaxial micro-extrusion technique that enables us to take advantage of triboelectric energy generation and custom build sensors to fit anywhere....
Published: 3/5/2021   |   Inventor(s): Blake Johnson, Yuxin Tong, John Robertson, Xiaoting Jia, Ziang Feng
Keywords(s):  
Category(s): Engineering, Biotechnology, Materials, Biomedical, Devices, Diagnostic, Energy
Cyclic gamma-Amino Acids and Peptoid Foldamers
Isonipecotic acid provides a stable scaffold with the potential for useful functionalization. Changing the side chains at the β- or γ-positions in the piperidyl ring will tune a peptide towards its biological target or catalytic function. Modifications at these positions is expected to have little effect on the chair conformation adopted...
Published: 6/13/2017   |   Inventor(s): Jatinder Josan, Robert Grams
Keywords(s):  
Category(s): Medical, Biomedical, Biology, Biotechnology, Chemicals, Drug Delivery, Drug Discovery
Tissue-Conforming Microfluidic Devices
A device that establishes fluidic interfaces with biological tissue for the purposes of isolating biological information and delivering therapeutic material to the biological tissue.
Published: 6/8/2017   |   Inventor(s): Blake Johnson, John Robertson, Manjot Singh, Yuxin Tong, Alexander Haring
Keywords(s):  
Category(s): Medical, Biomedical, Biotechnology, Devices
Enzymatic Biotransformation of Sucrose to Myo-Inositol Via Non-Natural Pathways and Thereof
We constructed in vitro enzymatic pathways that can convert sucrose to myo-inositol and fructose. Myo-inositol is vitamin V8, which has been widely used in the pharmaceutical, drink, food, feed, and cosmetic industries. Without product separation, a mixture of inositol and fructose will be a perfect functional sweetener, which may be directly added...
Published: 3/3/2017   |   Inventor(s): Yi-Heng Percival Zhang, Chun You, Chao Zhong
Keywords(s):  
Category(s): Biomedical, Biotechnology
Biometric Identification and Authentication Using Cardiac Signals
This paper considers signals from the cardiovascular system for possible use in biometric authentication. The signals of particular interest here derive from photoplethysmography (PPG), which refers to the use of illumination-based sensors that are sensitive to volumetric changes as blood travels through the body. Photoplethysmography sensors have been...
Published: 9/12/2016   |   Inventor(s): Abhijit Sarkar, Lynn Abbott, Zachary Doerzaph
Keywords(s):  
Category(s): Biotechnology
Bamboo Fiber Modified Asphalt Mixture
This invention utilizes abundant natural resources of bamboo fiber to mix with asphalt. The raw material is cheap and readily available. The manufacturing process is simple, molding easy, non-toxic and environmentally friendly. The prepared bamboo fiber modified asphalt mixture has good high temperature performance and resistance to water damage performance....
Published: 6/27/2016   |   Inventor(s): Zhangjing Chen, Yanping Sheng
Keywords(s):  
Category(s): Biotechnology
Producing Eicosapentaenoic Acid (EPA) from Biodiesel-derived Crude Glycerol
A novel fungal fermentation process has been developed which converts crude glycerol, a major byproduct of the biodiesel industry, into eicosapentaenoic acid (EPA), an important omega-3 highly unsaturated fatty acid. Biodiesel production is rising exponentially which is creating an urgent need to develop new markets for large quantities of crude glycerol....
Published: 6/20/2016   |   Inventor(s): Zhiyou Wen, Sneha Athalye
Keywords(s): Agriculture/Process Engineering, Biotechnology
Category(s): Biotechnology
Universal-Spatial Robotic Tail Mechanism
The Universal-Spatial Robotic Tail (USRT) is a hybrid robotic manipulator that combines an elastic back bone of a continuum robot with a series serial chain of universal joints as the tail structure. These universal joints allow relative yaw and pitch between individual bodies. Individual segments are created by terminating actuation cabling at a given...
Published: 5/3/2016   |   Inventor(s): Pinhas Ben-Tzvi, William Rone, Wael Saab
Keywords(s):  
Category(s): Engineering, Medical, Biomedical, Biotechnology, Biology, Electrical, Devices
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