Search Results - Drug+Discovery

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Mitochondrial complex II mutated SDHD cell line
The HEK293ΔSDHD cell line expresses a CRISPR/Cas9 mutated nuclear encoded subunit, SDHD, of mitochondrial complex II (succinate dehydrogenase). This cell line has been shown to significantly alter the function of complex II (CII) of the mitochondrial electron transport chain and displays disruptions to SDHD that mimic clinical presentations of...
Published: 10/11/2021   |   Inventor(s): Aloka Bandara, Joshua Drake, David Brown
Keywords(s):  
Category(s): Biotechnology, Drug Discovery
HEK293ΔNDUFS2 Cell Line
The HEK293ΔNDUFS2 cell line expresses a CRISPR/Cas9 mutated NDUFS2, shown to significantly alter the function of complex I (CI) of the mitochondrial electron transport chain. This NDUFS2 mutant cell line displays disruptions to NDUFS2 that mimic isolated complex I deficiency and can be used as a powerful model of several types of mitochondrial...
Published: 10/11/2021   |   Inventor(s): Aloka Bandara, David Brown
Keywords(s):  
Category(s): Biotechnology, Drug Discovery
Orally Active Tetracyclic Antimalarial Compound
THE CHALLENGE While current malarial drugs are able to protect against some strains, new malarial drugs are urgently needed to combat drug-resistant malaria infection. Also, current malarial drugs cannot be administered orally, which reduces the potential for safe drug delivery. OUR SOLUTION Dr. Paul Carlier and his team have discovered a structurally...
Published: 3/5/2021   |   Inventor(s): Paul Carlier, Sha Ding, Jopaul Mathew, Kevin Kunz, Max Totrov, Maria Cassera
Keywords(s):  
Category(s): Drug Discovery
Cyclic gamma-Amino Acids and Peptoid Foldamers
Isonipecotic acid provides a stable scaffold with the potential for useful functionalization. Changing the side chains at the β- or γ-positions in the piperidyl ring will tune a peptide towards its biological target or catalytic function. Modifications at these positions is expected to have little effect on the chair conformation adopted...
Published: 6/13/2017   |   Inventor(s): Jatinder Josan, Robert Grams
Keywords(s):  
Category(s): Medical, Biomedical, Biology, Biotechnology, Chemicals, Drug Delivery, Drug Discovery
Novel Peptides Stimulate the Formation of Inhibitory Brain Synapses
This invention describes a novel compound with prominent commercial value as a therapeutic treatment for neural conditions such as, autism, epilepsy, and schizophrenia. These disorders have been linked to inhibitory synapse defects formed by interneurons in the hippocampal region of the brain. Researchers at Virginia Tech have synthesized peptides to...
Published: 9/24/2014   |   Inventor(s): Michael Fox, Jianmin Su
Keywords(s):  
Category(s): Medical, Biology, Biomedical, Biotechnology, Chemicals, Diagnostic, Drug Discovery, Therapeutic
Human Carbohydrate Binding Protein for Modulation of Immune Responses
We have identified a putative receptor of the human innate immune system (expressed on lung epithelial cells and macrophages thus far) that binds to carbohydrate ligands such as chitin and potentially cellulose. We have shown that knocking down the gene for this receptor with siRNAs in lung epithelial cells in vitro results in dampening of the innate...
Published: 8/12/2014   |   Inventor(s): Christopher Lawrence, Brad Howard, Liwu Li
Keywords(s):  
Category(s): Drug Discovery
New Antidepressant Compounds (3)
Currently available antidepressant drugs treat only 70% of persons diagnosed with depressive illness. These drugs show a profile of blocking reuptake of serotonin and norepinephrine. Several lines of evidence, including the NIH STAR*D study suggest that addition of a dopamine reuptake-blocking action could treat refractory depressed individuals. ...
Published: 4/11/2014   |   Inventor(s): Paul Carlier, Christopher Monceaux, Tom Simpson, Mike Wood, Mark Chapdelaine, Dan Hill, Jim Kang, Jim Woods, Elliott Richelson, Abdul Fauq, Dola Sinha
Keywords(s):  
Category(s): Drug Discovery
New Antidepressant Compounds (2)
Currently available antidepressant drugs treat only 70% of persons diagnosed with depressive illness. These drugs show a profile of blocking reuptake of serotonin and norepinephrine. Several lines of evidence, including the NIH STAR*D study suggest that addition of a dopamine reuptake-blocking action could treat refractory depressed individuals. ...
Published: 4/11/2014   |   Inventor(s): Paul Carlier, Christopher Monceaux, Tom Simpson, Mike Wood, Mark Chapdelaine, Dan Hill, Jim Kang, Jim Woods, Elliott Richelson, Abdul Fauq, Dola Sinha
Keywords(s):  
Category(s): Drug Discovery
New Antidepressant Compounds (1)
Currently available antidepressant drugs treat only 70% of persons diagnosed with depressive illness. These drugs show a profile of blocking reuptake of serotonin and norepinephrine. Several lines of evidence, including the NIH STAR*D study suggest that addition of a dopamine reuptake-blocking action could treat refractory depressed individuals. ...
Published: 4/11/2014   |   Inventor(s): Paul Carlier, Christopher Monceaux, Tom Simpson, Mike Wood, Mark Chapdelaine, Dan Hill, Jim Kang, Jim Woods, Elliott Richelson, Abdul Fauq, Dola Sinha
Keywords(s): Medical/Therapeutic
Category(s): Drug Discovery
Interior 5D Micro-CT
Atherosclerosis is the leading cause of death in the developed countries at tremendous social and healthcare costs. Since mice as models of human diseases have been widely used in atherosclerosis research, the goal of this technology-driven project is to develop the most advanced micro-CT tool for imaging of atherosclerosis plaques in live mice. The...
Published: 4/1/2014   |   Inventor(s): Guohua Cao
Keywords(s):  
Category(s): Medical, Diagnostic, Drug Discovery, Imaging
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