Search Results - Drug Discovery

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Cyclic gamma-Amino Acids and Peptoid Foldamers
Isonipecotic acid provides a stable scaffold with the potential for useful functionalization. Changing the side chains at the β- or γ-positions in the piperidyl ring will tune a peptide towards its biological target or catalytic function. Modifications at these positions is expected to have little effect on the chair conformation adopted...
Published: 6/13/2017   |   Inventor(s): Jatinder Josan, Robert Grams
Keywords(s):  
Category(s): Medical, Biomedical, Biology, Biotechnology, Chemicals, Drug Delivery, Drug Discovery
Novel Peptides Stimulate the Formation of Inhibitory Brain Synapses
This invention describes a novel compound with prominent commercial value as a therapeutic treatment for neural conditions such as, autism, epilepsy, and schizophrenia. These disorders have been linked to inhibitory synapse defects formed by interneurons in the hippocampal region of the brain. Researchers at Virginia Tech have synthesized peptides ...
Published: 9/24/2014   |   Inventor(s): Michael Fox, Jianmin Su
Keywords(s):  
Category(s): Medical, Biology, Biomedical, Biotechnology, Chemicals, Diagnostic, Drug Discovery, Therapeutic
Human Carbohydrate Binding Protein for Modulation of Immune Responses
We have identified a putative receptor of the human innate immune system (expressed on lung epithelial cells and macrophages thus far) that binds to carbohydrate ligands such as chitin and potentially cellulose. We have shown that knocking down the gene for this receptor with siRNAs in lung epithelial cells in vitro results in dampening of the inna...
Published: 8/12/2014   |   Inventor(s): Christopher Lawrence, Brad Howard, Liwu Li
Keywords(s):  
Category(s): Drug Discovery
New Antidepressant Compounds (3)
Currently available antidepressant drugs treat only 70% of persons diagnosed with depressive illness. These drugs show a profile of blocking reuptake of serotonin and norepinephrine. Several lines of evidence, including the NIH STAR*D study suggest that addition of a dopamine reuptake-blocking action could treat refractory depressed individuals. ...
Published: 4/11/2014   |   Inventor(s): Paul Carlier, Christopher Monceaux, Tom Simpson, Mike Wood, Mark Chapdelaine, Dan Hill, Jim Kang, Jim Woods, Elliott Richelson, Abdul Fauq, Dola Sinha
Keywords(s):  
Category(s): Drug Discovery
New Antidepressant Compounds (2)
Currently available antidepressant drugs treat only 70% of persons diagnosed with depressive illness. These drugs show a profile of blocking reuptake of serotonin and norepinephrine. Several lines of evidence, including the NIH STAR*D study suggest that addition of a dopamine reuptake-blocking action could treat refractory depressed individuals. ...
Published: 4/11/2014   |   Inventor(s): Paul Carlier, Christopher Monceaux, Tom Simpson, Mike Wood, Mark Chapdelaine, Dan Hill, Jim Kang, Jim Woods, Elliott Richelson, Abdul Fauq, Dola Sinha
Keywords(s):  
Category(s): Drug Discovery
New Antidepressant Compounds (1)
Currently available antidepressant drugs treat only 70% of persons diagnosed with depressive illness. These drugs show a profile of blocking reuptake of serotonin and norepinephrine. Several lines of evidence, including the NIH STAR*D study suggest that addition of a dopamine reuptake-blocking action could treat refractory depressed individuals. ...
Published: 4/11/2014   |   Inventor(s): Paul Carlier, Christopher Monceaux, Tom Simpson, Mike Wood, Mark Chapdelaine, Dan Hill, Jim Kang, Jim Woods, Elliott Richelson, Abdul Fauq, Dola Sinha
Keywords(s): Medical/Therapeutic
Category(s): Drug Discovery
Interior 5D Micro-CT
Atherosclerosis is the leading cause of death in the developed countries at tremendous social and healthcare costs. Since mice as models of human diseases have been widely used in atherosclerosis research, the goal of this technology-driven project is to develop the most advanced micro-CT tool for imaging of atherosclerosis plaques in live mice. Th...
Published: 4/1/2014   |   Inventor(s): Guohua Cao
Keywords(s):  
Category(s): Medical, Diagnostic, Drug Discovery, Imaging
Methods For Therapeutic Targeting Cancer Stem Cells
Patients with the brain cancer glioblastoma have about a year to live once diagnosed. Glioblastoma kills quickly as it grows aggressively and patients develop resistance to the anti-cancer drug temozolomide. Studies by a team at Virginia Tech indicate that a protein called Cx43 may hold the key to temozolomide resistance. Our researchers have found...
Published: 2/6/2014   |   Inventor(s): Zhi Sheng, Robert Gourdie
Keywords(s):  
Category(s): Medical, Biology, Animal/Veterinary, Biomedical, Biotechnology, Therapeutic, Drug Delivery, Drug Discovery, Drug Screening, Gene Therapy
A Drug and Vaccine Target for Malaria
A novel protein, HDP, from Plasmodium and related parasites is a target for therapeutic intervention in diseases caused by the malarial parasites. US Patent 7,438,916
Published: 9/11/2012   |   Inventor(s): Dharmendar Rathore, Dewal Jani, Rana Nagarkatti
Keywords(s): Pharmaceuticals & Biotechnology
Category(s): Drug Discovery
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