Search Results - Medical

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Nanoparticle-based Nicotine Nanovaccine
THE CHALLENGE: Tobacco smoking is one of the largest public health threats the world has ever faced and results in over seven million deaths annually world wide. Smoking cessation is a difficult and largely unsuccessful undertaking; only 3-5% of unassisted smokers are able to remain abstinent for more than six months, and the use of pharmacological...
Published: 7/23/2021   |   Inventor(s): Chenming (mike) Zhang, Zongmin Zhao
Keywords(s):  
Category(s): Medical
Implant for Plantar Plate Repair
THE CHALLENGE The plantar plate is a deep fibrocartilaginous structure found in the foot whose primary role is to stabilize metatarsophalangeal joints and other structures; unfortunately, it can tear when inflamed or overworked as a result of running or other activities. Other than pain and discomfort, plantar plate tears can also cause the second...
Published: 7/7/2021   |   Inventor(s): Demitria Poulos, Logan Dickinson, Skye Carlson, Zachary Kozar, Jennifer Wayne, Vincent Wang, John Clements
Keywords(s):  
Category(s): Biomedical, Devices, Medical
Potent Antimalarial Compound
THE CHALLENGE Malaria is a life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitos and is a significant world health problem. The disease kills 430,000 people per year and sickens over 2,000,000. The development of a successful malaria vaccine is still decades away, and malaria...
Published: 4/13/2021   |   Inventor(s): Paul Carlier, Max Totrov, Maria Cassera
Keywords(s):  
Category(s): Medical, Biomedical
Cyclic gamma-Amino Acids and Peptoid Foldamers
Isonipecotic acid provides a stable scaffold with the potential for useful functionalization. Changing the side chains at the β- or γ-positions in the piperidyl ring will tune a peptide towards its biological target or catalytic function. Modifications at these positions is expected to have little effect on the chair conformation adopted...
Published: 6/13/2017   |   Inventor(s): Jatinder Josan, Robert Grams
Keywords(s):  
Category(s): Medical, Biomedical, Biology, Biotechnology, Chemicals, Drug Delivery, Drug Discovery
Tissue-Conforming Microfluidic Devices
A device that establishes fluidic interfaces with biological tissue for the purposes of isolating biological information and delivering therapeutic material to the biological tissue.
Published: 6/8/2017   |   Inventor(s): Blake Johnson, John Robertson, Manjot Singh, Yuxin Tong, Alexander Haring
Keywords(s):  
Category(s): Medical, Biomedical, Biotechnology, Devices
Method of Reducing Thermal Damage During Electroporation-Based Treatments and Therapies Using Minimal Energy Electrical Pulses
Electroporation is a process by which intense electric fields generate nano-scale defects within the cell membrane. These defects allow molecular exchange between the cell interior and the extracellular environment. We have developed a method by which a minimal amount of energy may be delivered to a cell suspension that will render the cells permeable...
Published: 2/6/2017   |   Inventor(s): Daniel Sweeney, Rafael Davalos, James Weaver, T.r. Gowrishankar, Reuben Seongwoo Son
Keywords(s):  
Category(s): Medical
System and Method of Stationary Source Computed Tomography
Cardiovascular computing tomography (CVCT) has been successfully applied for the diagnosis of a series of heart diseases. However, the limitations of temporal and spatial resolution and radiation dose inhibit the utilization of CVCT for more clinical applications. The specific primary bottlenecks fo the current CVCT include the difficulties of the synchronization...
Published: 11/21/2016   |   Inventor(s): Guohua Cao, Ge Wang
Keywords(s):  
Category(s): Medical, Devices, Diagnostic, Imaging
Automatic Centerline Isolation and Continuous Width Measurements Between Two Edges
This program takes any image with two nearly-parallel edges and identifies the centerline between them. During that process, the program measures the distance between those edges at each point along the centerline, resulting in a continuous width measurement between the two edges. This information is generated within seconds and can be used to identify...
Published: 9/26/2016   |   Inventor(s): Tristan Raisch, Steven Poelzing, Rengasayee Veeraraghavan
Keywords(s):  
Category(s): Medical, Engineering
Interactive Feature Space Explorer
By their local dependence on different biological, chemical and structural tissue properties, biomedical imaging signal generating mechanisms provide the detection of tissue transformations for diagnostic and/or prognostic purposes. Whereas multimodal imaging improves inaccuracies originating from signal overlaps between malignant and benign conditions,...
Published: 6/30/2016   |   Inventor(s): Alpay Ozcan
Keywords(s):  
Category(s): Medical, Imaging, Diagnostic
Universal-Spatial Robotic Tail Mechanism
The Universal-Spatial Robotic Tail (USRT) is a hybrid robotic manipulator that combines an elastic back bone of a continuum robot with a series serial chain of universal joints as the tail structure. These universal joints allow relative yaw and pitch between individual bodies. Individual segments are created by terminating actuation cabling at a given...
Published: 5/3/2016   |   Inventor(s): Pinhas Ben-Tzvi, William Rone, Wael Saab
Keywords(s):  
Category(s): Engineering, Medical, Biomedical, Biotechnology, Biology, Electrical, Devices
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