Search Results - aloka+bandara

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Mitochondrial complex II mutated SDHD cell line
The HEK293ΔSDHD cell line expresses a CRISPR/Cas9 mutated nuclear encoded subunit, SDHD, of mitochondrial complex II (succinate dehydrogenase). This cell line has been shown to significantly alter the function of complex II (CII) of the mitochondrial electron transport chain and displays disruptions to SDHD that mimic clinical presentations of...
Published: 10/11/2021   |   Inventor(s): Aloka Bandara, Joshua Drake, David Brown
Keywords(s):  
Category(s): Biotechnology, Drug Discovery
HEK293ΔNDUFS2 Cell Line
The HEK293ΔNDUFS2 cell line expresses a CRISPR/Cas9 mutated NDUFS2, shown to significantly alter the function of complex I (CI) of the mitochondrial electron transport chain. This NDUFS2 mutant cell line displays disruptions to NDUFS2 that mimic isolated complex I deficiency and can be used as a powerful model of several types of mitochondrial...
Published: 10/11/2021   |   Inventor(s): Aloka Bandara, David Brown
Keywords(s):  
Category(s): Biotechnology, Drug Discovery