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Cyclic gamma-Amino Acids and Peptoid Foldamers
Isonipecotic acid provides a stable scaffold with the potential for useful functionalization. Changing the side chains at the β- or γ-positions in the piperidyl ring will tune a peptide towards its biological target or catalytic function. Modifications at these positions is expected to have little effect on the chair conformation adopted...
Published: 6/13/2017   |   Inventor(s): Jatinder Josan, Robert Grams
Keywords(s):  
Category(s): Medical, Biomedical, Biology, Biotechnology, Chemicals, Drug Delivery, Drug Discovery
Universal-Spatial Robotic Tail Mechanism
The Universal-Spatial Robotic Tail (USRT) is a hybrid robotic manipulator that combines an elastic back bone of a continuum robot with a series serial chain of universal joints as the tail structure. These universal joints allow relative yaw and pitch between individual bodies. Individual segments are created by terminating actuation cabling at a g...
Published: 5/3/2016   |   Inventor(s): Pinhas Ben-Tzvi, William Rone, Wael Saab
Keywords(s):  
Category(s): Engineering, Medical, Biomedical, Biotechnology, Biology, Electrical, Devices
Novel Compositions and Methods for Hemichannel Inhibition
The compositions GaPS and methods for their use are provided. GaPS can have potent inhibitory and clinically useful effects on gap junction and structurally related hemichannels. Inhibiting these channels has proven to have clinical benefits in the injury response and for numerous diseases, including in reducing excess inflammation, scarring and fi...
Published: 7/2/2015   |   Inventor(s): Robert Gourdie, Linda Jourdan
Keywords(s):  
Category(s): Medical, Biology, Biotechnology, Biomedical, Chemicals, Drug Delivery
Novel Peptides Stimulate the Formation of Inhibitory Brain Synapses
This invention describes a novel compound with prominent commercial value as a therapeutic treatment for neural conditions such as, autism, epilepsy, and schizophrenia. These disorders have been linked to inhibitory synapse defects formed by interneurons in the hippocampal region of the brain. Researchers at Virginia Tech have synthesized peptides ...
Published: 9/24/2014   |   Inventor(s): Michael Fox, Jianmin Su
Keywords(s):  
Category(s): Medical, Biology, Biomedical, Biotechnology, Chemicals, Diagnostic, Drug Discovery, Therapeutic
Methods For Therapeutic Targeting Cancer Stem Cells
Patients with the brain cancer glioblastoma have about a year to live once diagnosed. Glioblastoma kills quickly as it grows aggressively and patients develop resistance to the anti-cancer drug temozolomide. Studies by a team at Virginia Tech indicate that a protein called Cx43 may hold the key to temozolomide resistance. Our researchers have found...
Published: 2/6/2014   |   Inventor(s): Zhi Sheng, Robert Gourdie
Keywords(s):  
Category(s): Medical, Biology, Animal/Veterinary, Biomedical, Biotechnology, Therapeutic, Drug Delivery, Drug Discovery, Drug Screening, Gene Therapy
Protective Coating Process for Biological Agents
The process that we are describing provides for coating biological control agents such as entomopathogenic spores in a closely controlled environment. It is designed to minimize the potential detrimental effects of hydration and dehydration of the agents which may reduce their field use efficacy and storage shelf life. The process should prove to b...
Published: 3/25/2013   |   Inventor(s): Donald Mullins, Sandra Gabbert
Keywords(s):  
Category(s): Agriculture, Biology, Chemicals
Application of Vacuum to Control Wood Insects
This technology is a new process to control wood-infesting insects has been effective in killing longhorned beetle larvae in structural wood with different moisture contents. It can be applied to other pests, including lyctid, anobiid, and buprestid beetles that infest wood. Current methods for wood sanitation include the use of gas fumigants, su...
Published: 9/3/2012   |   Inventor(s): Zhangjing Chen, Marshall White, William Robinson
Keywords(s): Agriculture/Pest Control
Category(s): Agriculture, Biology
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