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Novel Electrolyte Formulation to Enhance Cardiac Function
­THE CHALLENGE There are over 350,000 out-of-hospital cardiac arrests each year, with each patient seen by EMS receiving a liter of crystalloid solution (usually 0.9% saline). Only about two thirds of those patients have a pulse return; the remainder die from the condition called pulseless electrical activity (PEA) or electromechanical disassociation....
Published: 4/22/2022   |   Inventor(s): Steven Poelzing, David King
Category(s): Biomedical
Highly Modifiable Anti-Viral Scaffold
THE CHALLENGE New infectious diseases for which there are no effective pharmaceuticals available are a significant threat to the global population. Infections that are more difficult to treat, such as Mycobacterium tuberculosis (TB), methicillin-resistant Staphylococcus aureus (MRSA), and SARS-CoV-2 (causative agent of COVID-19) present a unique challenge....
Published: 8/18/2022   |   Inventor(s): Joseph Merola, James Weger, Christine Duchane, Christina Chuong, Chad Bernier
Category(s): Biomedical
Large Animal Dystocia Simulator
THE CHALLENGE Dystocia, an abnormal or difficult birth often caused by a large or awkwardly positioned fetus, is a common and serious concern—particularly in cattle and horses. It is a major cause of fetal death and often requires veterinarian intervention. Properly training veterinarians for these events can be tricky, as there are very few...
Published: 9/9/2021   |   Inventor(s): Fawzy Elnady
Category(s): Biomedical
Implant for Plantar Plate Repair
THE CHALLENGE The plantar plate is a deep fibrocartilaginous structure found in the foot whose primary role is to stabilize metatarsophalangeal joints and other structures; unfortunately, it can tear when inflamed or overworked as a result of running or other activities. Other than pain and discomfort, plantar plate tears can also cause the second...
Published: 8/18/2022   |   Inventor(s): Demitria Poulos, Logan Dickinson, Skye Carlson, Zachary Kozar, Jennifer Wayne, Vincent Wang, John Clements
Category(s): Biomedical, Devices, Medical
Potent Antimalarial Compound
THE CHALLENGE Malaria is a life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitos and is a significant world health problem. The disease kills 430,000 people per year and sickens over 2,000,000. The development of a successful malaria vaccine is still decades away, and malaria...
Published: 4/14/2021   |   Inventor(s): Paul Carlier, Max Totrov, Maria Cassera
Category(s): Medical, Biomedical
3D Printable Multifunctional Fibers
THE CHALLENGE 3D printing has enabled the customized production of many objects and devices, but that technology currently only creates passive units. THE SOLUTION Researchers at Virginia Tech have developed a coaxial micro-extrusion technique that enables us to take advantage of triboelectric energy generation and custom build sensors to fit anywhere....
Published: 3/5/2021   |   Inventor(s): Blake Johnson, Yuxin Tong, John Robertson, Xiaoting Jia, Ziang Feng
Category(s): Engineering, Biotechnology, Materials, Biomedical, Devices, Diagnostic, Energy
A Recombinant Subunit Vaccine With Enhanced Immunity Against Porcine Epidemic Diarrhea Virus (PEDV)
Since its emergence in the United States in 2013, porcine epidemic diarrhea virus (PEDV) has devastated the U.S. swine industry causing immense economic losses. This invention report the creation of a subunit vaccine that can also enhance T cell immunity against PEDV, and thus such a vaccine will have significant commerical value to the swine industry...
Published: 11/27/2017   |   Inventor(s): Sakthivel Subramaniam, Yao-Wei Huang, Xiang-Jin Meng
Category(s): Animal/Veterinary, Biomedical
Cyclic gamma-Amino Acids and Peptoid Foldamers
Isonipecotic acid provides a stable scaffold with the potential for useful functionalization. Changing the side chains at the β- or γ-positions in the piperidyl ring will tune a peptide towards its biological target or catalytic function. Modifications at these positions is expected to have little effect on the chair conformation adopted...
Published: 11/27/2017   |   Inventor(s): Jatinder Josan, Robert Grams
Category(s): Medical, Biomedical, Biology, Biotechnology, Chemicals, Drug Delivery, Drug Discovery
Structure Illuminated Color X-ray Phase Imaging for Breast Cancer Screening
One in every nine women is expected to develop breast cancer in her life. Current mainstream screening technology is the mammography. Mammography suffers from a range of problems including low signal level, poor contrast, and radiation dose. It leads to severe over-diagnostic problems. In contrast, our breast cancer screening system with color X-ray...
Published: 1/6/2023   |   Inventor(s): Guohua Cao
Category(s): Biomedical, Devices, Diagnostic
Tissue-Conforming Microfluidic Devices
A device that establishes fluidic interfaces with biological tissue for the purposes of isolating biological information and delivering therapeutic material to the biological tissue.
Published: 11/30/2022   |   Inventor(s): Blake Johnson, John Robertson, Manjot Singh, Yuxin Tong, Alexander Haring
Category(s): Medical, Biomedical, Biotechnology, Devices
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