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Amorphous Solid Dispersions Using pH-responsive Cellulose Ethers to Improve Rifapentine Dissolution Properties
The efficacy of rifapentine, an oral antibiotic used in the treatment of tuberculosis, is reduced due to its degradation at gastric pH and low solubility at intestinal pH. We aimed to improve delivery properties in vitro by incorporating rifapentine into pH-responsive amorphous solid dispersions with commercially-available and novel cellulose ethers....
Published: 12/5/2017   |   Inventor(s): Nammalwar Sriranganathan, Kevin Edgar, Andrew Neilson, Brittany Nichols, Christopher Winslow
Category(s): Drug Delivery