Search Results - drug delivery

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Amorphous Solid Dispersions Using pH-responsive Cellulose Ethers to Improve Rifapentine Dissolution Properties
The efficacy of rifapentine, an oral antibiotic used in the treatment of tuberculosis, is reduced due to its degradation at gastric pH and low solubility at intestinal pH. We aimed to improve delivery properties in vitro by incorporating rifapentine into pH-responsive amorphous solid dispersions with commercially-available and novel cellulose ether...
Published: 12/5/2017   |   Inventor(s): Nammalwar Sriranganathan, Kevin Edgar, Andrew Neilson, Brittany Nichols, Christopher Winslow
Category(s): Drug Delivery
Cyclic gamma-Amino Acids and Peptoid Foldamers
Isonipecotic acid provides a stable scaffold with the potential for useful functionalization. Changing the side chains at the β- or γ-positions in the piperidyl ring will tune a peptide towards its biological target or catalytic function. Modifications at these positions is expected to have little effect on the chair conformation adopted...
Published: 6/13/2017   |   Inventor(s): Jatinder Josan, Robert Grams
Category(s): Medical, Biomedical, Biology, Biotechnology, Chemicals, Drug Delivery, Drug Discovery
Versatile Photo-Active Cages for Drug Delivery
For photodynamic therapy (PDT) to play the primary clinical role in the treatment of HNCs, an ideal photo-triggered method that addresses the weaknesses of traditional PDT must be developed. The nanoMOF platform that we have invented here has the potential to fill this critical need. (1) The intended organic shell of our nanoMOF serves as a key com...
Published: 2/6/2017   |   Inventor(s): Amanda Morris, Charity Epley, Tijana Grove, Kristina Roth
Category(s): Drug Delivery
Optimized Intravenous Solution as Adjuvant Pharmacotherapy
We developed an electrolytic range for an enhanced resuscitation fluid that enhances cardiac dynamics during administration of compounds known to have deliterious cardiac side-effects. The electrolytic composition of these solutions fall within the normal physiologic range of human plasma, and are therefore biocompatible with humans according to ou...
Published: 2/6/2017   |   Inventor(s): Steven Poelzing
Category(s): Drug Delivery
Ultrafast Micro-CT for Imaging Free-Moving Animals
All current small animal imaging requires some form of anesthetization. The anesthetization not only may interfere with the subject's pathophysiology under study, and also is a costive and skill-demanding process. The current invention will eliminate the need for administration of anesthesia during small animal micro-CT imaging experiments, thus le...
Published: 2/6/2017   |   Inventor(s): Guohua Cao
Keywords(s): Biotechnology/Imaging, Imaging, Medical/Imaging
Category(s): Biomedical, Devices, Diagnostic, Drug Delivery, Drug Screening, Gene Therapy
Polysaccharide - Bile Salt Conjugates
Novel amphiphilic polymers based on natural, renewable polysaccharides that can stabilize solid and liquid phase dispersions of otherwise poorly water soluble bioactive or other small molecules.
Published: 7/18/2016   |   Inventor(s): Kevin Edgar, Yifan Dong
Category(s): Drug Delivery
Synthesis of Hydroxyl-substituted Polysaccharide Derivatives
Selective and broadly useful chemistry for appending hydroxy-terminal groups to polysaccharide, useful for crosslinking for coatings and other applications, enhanced solubility and processing, and as a convenient handle for appending other functional groups such as for targeting, triggered release of drugs, adhesion, or other applications.
Published: 9/17/2015   |   Inventor(s): Kevin Edgar, Xiangtao Meng
Category(s): Drug Delivery
Novel Compositions and Methods for Hemichannel Inhibition
The compositions GaPS and methods for their use are provided. GaPS can have potent inhibitory and clinically useful effects on gap junction and structurally related hemichannels. Inhibiting these channels has proven to have clinical benefits in the injury response and for numerous diseases, including in reducing excess inflammation, scarring and fi...
Published: 7/2/2015   |   Inventor(s): Robert Gourdie, Linda Jourdan
Category(s): Medical, Biology, Biotechnology, Biomedical, Chemicals, Drug Delivery
Controlled Release of Antigen In Dendritic Cells Using pH-Sensitive Liposome-Polymeric Hybrid Nanoparticles
A nano delivery system that can stay stable during circulation in vivo, as well as enables rapid release of the encapsulated antigen in dendritic cells would be of great value in vaccine development. Here, we present the development of a nano hybrid particle consisting of a pH sensitive lipid shell and a poly (lactic-co-glycolic) acid (PLGA) core. ...
Published: 8/12/2014   |   Inventor(s): Chenming (Mike) Zhang, Yun Hu
Category(s): Drug Delivery
Methods For Therapeutic Targeting Cancer Stem Cells
Patients with the brain cancer glioblastoma have about a year to live once diagnosed. Glioblastoma kills quickly as it grows aggressively and patients develop resistance to the anti-cancer drug temozolomide. Studies by a team at Virginia Tech indicate that a protein called Cx43 may hold the key to temozolomide resistance. Our researchers have found...
Published: 2/6/2014   |   Inventor(s): Zhi Sheng, Robert Gourdie
Category(s): Medical, Biology, Animal/Veterinary, Biomedical, Biotechnology, Therapeutic, Drug Delivery, Drug Discovery, Drug Screening, Gene Therapy
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