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Mitochondrial complex II mutated SDHD cell line
The HEK293ΔSDHD cell line expresses a CRISPR/Cas9 mutated nuclear encoded subunit, SDHD, of mitochondrial complex II (succinate dehydrogenase). This cell line has been shown to significantly alter the function of complex II (CII) of the mitochondrial electron transport chain and displays disruptions to SDHD that mimic clinical presentations of...
Published: 10/11/2021   |   Inventor(s): Aloka Bandara, Joshua Drake, David Brown
Category(s): Biotechnology, Drug Discovery