Search Results - paul carlier

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Highly Species-Selective Insecticidal Carbamates for Mosquito Control
ABOUT THE TECHNOLOGYWith about 198 million cases and 584,000 deaths just in 2013, malaria has been and continues to be a prominent health concern all over the world. In some areas, the method of defense against the vector, Anopheles gambiae, is profoundly limited. For example, many of those in sub-Saharan Africa rely on insecticide-treated nets (I...
Published: 6/1/2015   |   Inventor(s): Joshua Hartsel, Ming Ma, Troy Anderson, Ranginee Choudhury, Paul Carlier, Jeffrey Bloomquist, Sally Paulson, Eric Wong
Keywords(s): Agriculture/Pest Control
Category(s): Chemicals, Biomedical
Structurally Novel Insecticides for the Malaria Mosquito
Structurally Novel Insecticides for the Malaria Mosquito:ABOUT THE TECHNOLOGYWith about 198 million cases and 584,000 deaths just in 2013, malaria has been and continues to be a prominent health concern all over the world. Only one class of approved insecticides, pyrethroids, is routinely used on insecticide-treated nets (ITNs), which have the pote...
Published: 6/1/2015   |   Inventor(s): Paul Carlier, Eugene Camerino, Dawn Wong, Jeffrey Bloomquist
Keywords(s): Agriculture/Pest Control
Category(s): Medical, Chemicals
Novel Methylerythritol Phosphate Pathway Inhibitors
The apicoplast is essential to the malaria parasite and its main function during asexual blood stages is to provide the isoprenoid precursor isopentenyl diphosphate (MEP) pathway. Without IPP, the parasite cannot synthesize isoprenoids; this IPP deficit is cytocidal and may also reduce the ability of the parasite to invade host cells. Since human...
Published: 10/29/2014   |   Inventor(s): Paul Carlier, Maria Belen Cassera, Emilio Merino, Zhong-Ke Yao
Keywords(s):  
Category(s): Medical, Agriculture, Animal/Veterinary, Biomedical, Therapeutic
New Antidepressant Compounds (3)
Currently available antidepressant drugs treat only 70% of persons diagnosed with depressive illness. These drugs show a profile of blocking reuptake of serotonin and norepinephrine. Several lines of evidence, including the NIH STAR*D study suggest that addition of a dopamine reuptake-blocking action could treat refractory depressed individuals. ...
Published: 4/11/2014   |   Inventor(s): Paul Carlier, Christopher Monceaux, Tom Simpson, Mike Wood, Mark Chapdelaine, Dan Hill, Jim Kang, Jim Woods, Elliott Richelson, Abdul Fauq, Dola Sinha
Keywords(s):  
Category(s): Drug Discovery
New Antidepressant Compounds (2)
Currently available antidepressant drugs treat only 70% of persons diagnosed with depressive illness. These drugs show a profile of blocking reuptake of serotonin and norepinephrine. Several lines of evidence, including the NIH STAR*D study suggest that addition of a dopamine reuptake-blocking action could treat refractory depressed individuals. ...
Published: 4/11/2014   |   Inventor(s): Paul Carlier, Christopher Monceaux, Tom Simpson, Mike Wood, Mark Chapdelaine, Dan Hill, Jim Kang, Jim Woods, Elliott Richelson, Abdul Fauq, Dola Sinha
Keywords(s):  
Category(s): Drug Discovery
New Antidepressant Compounds (1)
Currently available antidepressant drugs treat only 70% of persons diagnosed with depressive illness. These drugs show a profile of blocking reuptake of serotonin and norepinephrine. Several lines of evidence, including the NIH STAR*D study suggest that addition of a dopamine reuptake-blocking action could treat refractory depressed individuals. ...
Published: 4/11/2014   |   Inventor(s): Paul Carlier, Christopher Monceaux, Tom Simpson, Mike Wood, Mark Chapdelaine, Dan Hill, Jim Kang, Jim Woods, Elliott Richelson, Abdul Fauq, Dola Sinha
Keywords(s): Medical/Therapeutic
Category(s): Drug Discovery
Novel Small-Molecule Antidepressants
These potential antidepressant compounds have a novel mechanism of action – blockade of transporters for the neurotransmitters norepinephrine, serotonin, and dopamine. This novel “triple reuptake blockade” approach holds promise for a more effective and rapidly-acting antidepressant.
Published: 4/1/2014   |   Inventor(s): Paul Carlier, Elliott Richelson
Keywords(s): Pharmaceuticals & Biotechnology
Category(s): Medical, Biotechnology
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