Search Results - therapeutic

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Measurement-Based Care (MBC) Implementation Training Module
THE CHALLENGE: In 2019, over 20% of U.S. adults experienced mental illness, and that figure doubled during the COVID-19 pandemic. In addition to the personal, family, and community impacts of mental illness, serious mental illness causes over $193 billion in lost earnings each year in the U.S. Of those who did receive treatment, less than 10% of mental...
Published: 8/18/2022   |   Inventor(s): Lee Cooper, Alyssa Gatto, Sydney Jones, Hayoung Ko, Robert McNamara, Virginia O’Brien, Anita Kablinger
Category(s): Therapeutic
Novel Methylerythritol Phosphate Pathway Inhibitors
The apicoplast is essential to the malaria parasite and its main function during asexual blood stages is to provide the isoprenoid precursor isopentenyl diphosphate (MEP) pathway. Without IPP, the parasite cannot synthesize isoprenoids; this IPP deficit is cytocidal and may also reduce the ability of the parasite to invade host cells. Since humans...
Published: 11/27/2017   |   Inventor(s): Paul Carlier, Maria Belen Cassera, Emilio Merino, Zhong-Ke Yao
Category(s): Medical, Agriculture, Animal/Veterinary, Biomedical, Therapeutic
Novel Peptides Stimulate the Formation of Inhibitory Brain Synapses
This invention describes a novel compound with prominent commercial value as a therapeutic treatment for neural conditions such as, autism, epilepsy, and schizophrenia. These disorders have been linked to inhibitory synapse defects formed by interneurons in the hippocampal region of the brain. Researchers at Virginia Tech have synthesized peptides to...
Published: 11/27/2017   |   Inventor(s): Michael Fox, Jianmin Su
Category(s): Medical, Biology, Biomedical, Biotechnology, Chemicals, Diagnostic, Drug Discovery, Therapeutic
Methods For Therapeutic Targeting Cancer Stem Cells
Patients with the brain cancer glioblastoma have about a year to live once diagnosed. Glioblastoma kills quickly as it grows aggressively and patients develop resistance to the anti-cancer drug temozolomide. Studies by a team at Virginia Tech indicate that a protein called Cx43 may hold the key to temozolomide resistance. Our researchers have found...
Published: 11/27/2017   |   Inventor(s): Zhi Sheng, Robert Gourdie
Category(s): Medical, Biology, Animal/Veterinary, Biomedical, Biotechnology, Therapeutic, Drug Delivery, Drug Discovery, Drug Screening, Gene Therapy
Small Magnetite-Containing Anti-Retroviral Therapy (SMART) Nanoparticles
This invention is an approach for the delivery of anti-viral drugs in the form of dispersed nanoparticles. The invention consists of magnetite-polymer complexes with well-defined compositions, narrow size distributions, colloidal stability in physiological media, and transverse relaxivities comparable to or better than those of commercially available...
Published: 11/27/2017   |   Inventor(s): Richey Davis, Judy Riffle, Howard Gendelman
Category(s): Medical, Biomedical, Chemicals, Diagnostic, Materials, Nanotechnology, Therapeutic
Fiberoptic Microneedle Device for Convection-Enhanced Thermochemotherapy of Malignant Glioma
This invention allows diffuse convection-enhanced delivery of chemotherapy to tumors unreachable by direct surgical intervention. The device employs simultaneous co-delivery of fluid agents and laser energy at multiple infusion points to improve coverage of tumor margins. Previous similar methods have recently failed to meet clinical endpoints in Phase...
Published: 2/17/2021   |   Inventor(s): Christopher Rylander, Robert Hood, John Robertson, Marissa Nichole Rylander
Keywords(s): Medical/Device
Category(s): Therapeutic
Dinitro-Thiophene and 4-Chloro-Nitro-Thiazolide Tuberculosis Therapeutics
Treatment of tuberculosis caused by Mycobacterium tuberculosis continues to be difficult because of the emergence of drug-resistant strains throughout the world. As the frequency of multiply drug-resistant (MDR) and extremely drug-resistant (XDR) strains increases, the need for new anti-tuberculosis therapeutics has become a major area of concern throughout...
Published: 11/27/2017   |   Inventor(s): Joseph Falkinham, Paul Hoffman
Category(s): Therapeutic
Anti-Microbial Properties of Amino Acid Complexes of the Later Transition Metals
Antibiotic resistant strains of bacteria are more frequently reported and present an immediate and severe danger to many people. New manners of fighting these infections are being sought, with several particularly promising compounds being developed at Virginia Tech. The creation of transition metal complexes with effective anti-microbial properties...
Published: 11/27/2017   |   Inventor(s): Joseph Merola
Category(s): Medical, Chemicals, Materials, Biomedical, Therapeutic
Fiber Array for Optical Imaging and Therapeutics
A biomedical device that allows increased light penetration in skin and can substantially improve a variety of light-based therapeutic and diagnostic procedures.The device has an array of optically transparent fibers (either nano- or microscale in diameter) which are guided into a patient's skin by the simultaneous application of a guidance ferrule...
Published: 2/17/2021   |   Inventor(s): Christopher Rylander, Thomas Campbell, Ge Wang, Yong Xu, Mehmet Kosoglu
Keywords(s): Medical/Imaging
Category(s): Therapeutic, Biomedical
Conformationally-Constrained Paclitaxels as Anticancer Agents
This technology is a new class of paclitaxel analogs. The general structure includes a bridging bond that constrains the 3-D structure of the compound. The resulting conformation of the paclitaxel analog promotes binding to and polymerization of tubulin. US Patent 7,312,240
Published: 11/27/2017   |   Inventor(s): David Kingston, Thota Ganesh, James Snyder, Ami Lakdawala, Susan Bane
Keywords(s): Pharmaceuticals & Biotechnology
Category(s): Therapeutic, Biomedical