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Novel Methylerythritol Phosphate Pathway Inhibitors
The apicoplast is essential to the malaria parasite and its main function during asexual blood stages is to provide the isoprenoid precursor isopentenyl diphosphate (MEP) pathway. Without IPP, the parasite cannot synthesize isoprenoids; this IPP deficit is cytocidal and may also reduce the ability of the parasite to invade host cells. Since humans...
Published: 10/29/2014   |   Inventor(s): Paul Carlier, Maria Belen Cassera, Emilio Merino, Zhong-Ke Yao
Category(s): Medical, Agriculture, Animal/Veterinary, Biomedical, Therapeutic