Fiberoptic Microneedle Device for Convection-Enhanced Thermochemotherapy of Malignant Glioma

Description:
This invention allows diffuse convection-enhanced delivery of chemotherapy to tumors unreachable by direct surgical intervention. The device employs simultaneous co-delivery of fluid agents and laser energy at multiple infusion points to improve coverage of tumor margins. Previous similar methods have recently failed to meet clinical endpoints in Phase 3 FDA trials due to insufficient tumor coverage. This problem is caused by the differing hydraulic conductivities found in various cerebral structures, causing preferential fluid diffusion down certain pathways and insufficient fluid penetration in others. Our design seeks to overcome this difficulty by spreading many small volume injection points around a localized area in place of 1-4 large injection points. Our design also utilizes engineering solutions to improve diffusion from each injection point by raising local diffusion rates in the area and ensuring local pressure fields do not approach tissue damage thresholds.
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Fiber Array For Optical Imaging and Therapeutics US 371 Utility *United States 14/002,058   8/28/2013    
Fiber Array for Optical Imaging and Therapeutics Foreign Europe 12781846.6 9/27/2013    
Category(s):
Therapeutic
For Information, Contact:
Mike Miller
Senior Licensing Manager
Virginia Tech Intellectual Properties, Inc.
(540) 443-9228
mmiller@vtip.org
Inventors:
Christopher Rylander
Robert Hood
John Robertson
Marissa Nichole Rylander
Keywords:
Medical/Device
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