Highly Species-Selective Insecticidal Carbamates for Mosquito Control

Description:

ABOUT THE TECHNOLOGY

With about 198 million cases and 584,000 deaths just in 2013, malaria has been and continues to be a prominent health concern all over the world. In some areas, the method of defense against the vector, Anopheles gambiae, is profoundly limited.  For example, many of those in sub-Saharan Africa rely on insecticide-treated nets (ITNs) as their only protection.  ITNs have the potential to reduce malaria transmission by 50%. However, only one class of approved insecticides, pyrethroids, is routinely used on ITNs.  With the recent dramatic increase of pyrethroid resistance, there is a demand for an alternative insecticide.  In fact, pyrethoid resistance now exceeds 1,000-fold. 

Carbamates are currently used to control agricultural pests and disease vectors in areas where human contact is unlikely.  These compounds inhibit acetylcholinesterase (AchE) in both insects and humans, inflicting safety concerns, and are therefore not used on ITNs.  Researchers at Virginia Tech have effectively identified classes of carbamates that have high selectivity for Anopheles gambiae AChE (AgAChE) over human AchE (MdAChE). 

APPLICATIONS

These compounds, which consist of phenyl N-methyl carbamates, show selection towards the inhibition of AgAChE relative to MdAChE.  Thus, these carbamates are toxic to mosquitoes but not to humans and they can be safely used to target Anopheles gambiae in close proximity to humans.  Particularly, these carbamates can be used as an alternative insecticide for ITNs, providing a solution as pyrethroid resistance continues to increase.

U.S. patents 8,129,428 and 8,618,162 have been issued for this invention and are available for licensing.
  

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Insecticidal Carbamates Exhibiting Species-Selective Inhibition of Acetylcholinesterase (AChE) US Utility *United States 12/209,301 8,129,428 9/12/2008 3/6/2012 9/14/2030
Insecticidal Carbamates Exhibiting Species-Selective Inhibition of Acetylcholinesterase (AChE) Foreign OAPI regional 1201000096   3/12/2010    
Insecticidal Carbamates Exhibiting Species-Selective Inhibition of Acetylcholinesterase (AChE) Foreign South Africa 2010/01821 2010/01821 3/12/2010 5/25/2011 9/12/2028
Insecticidal Carbamates Exhibiting Species-Selective Inhibition of Acetylcholinesterase (AChE) Foreign Nigeria NG/C/2010/232 NG/C/2010/232 3/12/2010 4/4/2010 9/12/2028
Insecticidal Carbamates Exhibiting Species-Selective Inhibition of Acetyl Cholinesterase (AChE) US Continuation *United States 13/358,586 8,618,162 1/26/2012 12/31/2013 9/12/2028
Category(s):
Chemicals
Biomedical
For Information, Contact:
Rob Whitehead
Senior Licensing Manager
Virginia Tech Intellectual Properties, Inc.
(540) 443-9219
rwhitehead@vtip.org
Inventors:
Joshua Hartsel
Ming Ma
Troy Anderson
Ranginee Choudhury
Paul Carlier
Jeffrey Bloomquist
Sally Paulson
Eric Wong
Keywords:
Agriculture/Pest Control
© 2017. All Rights Reserved. Powered by Inteum