Search Results - chenming+(mike)+zhang

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Nanoparticle-based Nicotine Nanovaccine
THE CHALLENGE: Tobacco smoking is one of the largest public health threats the world has ever faced and results in over seven million deaths annually world wide. Smoking cessation is a difficult and largely unsuccessful undertaking; only 3-5% of unassisted smokers are able to remain abstinent for more than six months, and the use of pharmacological...
Published: 7/23/2021   |   Inventor(s): Chenming (mike) Zhang, Zongmin Zhao
Keywords(s):  
Category(s): Medical
A Novel Lipid-Polymeric Hybrid Nanoparticle Based Nicotine Vaccine to Treat Nicotine Addiction
Tobacco addiction has consistently been the top preventable cause of many serious diseases, and results in huge mortality, morbidity, and economic loss in recent decades. Despite the strong willingness to quit smoking, most of the smokers cannot achieve long term abstinence without medical interventions. However, current FDA approved pharmacological...
Published: 1/4/2016   |   Inventor(s): Chenming (mike) Zhang, Zongmin Zhao, Yun Hu
Keywords(s):  
Category(s): Medical, Biomedical
Controlled Release of Antigen In Dendritic Cells Using pH-Sensitive Liposome-Polymeric Hybrid Nanoparticles
A nano delivery system that can stay stable during circulation in vivo, as well as enables rapid release of the encapsulated antigen in dendritic cells would be of great value in vaccine development. Here, we present the development of a nano hybrid particle consisting of a pH sensitive lipid shell and a poly (lactic-co-glycolic) acid (PLGA) core. This...
Published: 8/12/2014   |   Inventor(s): Chenming (mike) Zhang, Yun Hu
Keywords(s):  
Category(s): Drug Delivery