Search Results - kevin edgar

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Amorphous Solid Dispersions Using pH-responsive Cellulose Ethers to Improve Rifapentine Dissolution Properties
The efficacy of rifapentine, an oral antibiotic used in the treatment of tuberculosis, is reduced due to its degradation at gastric pH and low solubility at intestinal pH. We aimed to improve delivery properties in vitro by incorporating rifapentine into pH-responsive amorphous solid dispersions with commercially-available and novel cellulose ether...
Published: 12/5/2017   |   Inventor(s): Nammalwar Sriranganathan, Kevin Edgar, Andrew Neilson, Brittany Nichols, Christopher Winslow
Keywords(s):  
Category(s): Drug Delivery
Polysaccharide - Bile Salt Conjugates
Novel amphiphilic polymers based on natural, renewable polysaccharides that can stabilize solid and liquid phase dispersions of otherwise poorly water soluble bioactive or other small molecules.
Published: 7/18/2016   |   Inventor(s): Kevin Edgar, Yifan Dong
Keywords(s):  
Category(s): Drug Delivery
Polysaccharide-Based Copolymer Materials
Efficient new method for conversion of inexpensive, commercial cellulose esters and cellulose ethers to more functional products with high performance in delivery of proteins, genes, anionic drugs, and other anionic species, whether in medicine, food, personal care, agriculture, or other delivery applications.
Published: 3/10/2016   |   Inventor(s): Kevin Edgar, Shu Liu
Keywords(s):  
Category(s): Chemicals, Biomedical
Cellulose Derivatives for Solid Dispersion
New cellulosic polymers are described which have substantial water affinity and thereby have superior ability to stabilize hydrophobic species in water, and release hydrophobic species to form supersaturated solutions. They have strong potential for controlled release, amorphous solid dispersion, waterborne coatings, and other aqueous dispersion ap...
Published: 12/17/2015   |   Inventor(s): Kevin Edgar, Hale Cigdem Arca, Lynne Taylor
Keywords(s):  
Category(s): Biotechnology
Cellulose Ethers for Solubility Enhancement
The technology is a novel method for making functional materials from sustainable, renewable polysaccharides. It focuses on making materials that have good solubility, dispersability, or otherwise have high affinity in and for water. These materials can be designed to contain virtually any functional group, thereby permitting the designer to equip ...
Published: 9/21/2015   |   Inventor(s): Kevin Edgar, Yifan Dong, Jacob Troutman
Keywords(s):  
Category(s): Materials
Synthesis of Hydroxyl-substituted Polysaccharide Derivatives
Selective and broadly useful chemistry for appending hydroxy-terminal groups to polysaccharide, useful for crosslinking for coatings and other applications, enhanced solubility and processing, and as a convenient handle for appending other functional groups such as for targeting, triggered release of drugs, adhesion, or other applications.
Published: 9/17/2015   |   Inventor(s): Kevin Edgar, Xiangtao Meng
Keywords(s):  
Category(s): Drug Delivery
Water-Dispersible Polysaccharide Derivatives
Large and varied family of novel water-dispersible polymers based on renewable polysaccharides. May be designed for high or low water affinity of applied film, and for various functionality (e.g. strength, flexibility, impact resistance, antibacterial property). Extremely flexible and efficient synthetic process.Commercial applications include: wat...
Published: 4/1/2014   |   Inventor(s): Kevin Edgar, Xiangtao Meng
Keywords(s):  
Category(s): Chemicals
Novel Polysaccharide Derivatives and Process for Making Them
Novel method allows for rapid, simple, versatile and highly efficient synthesis of omega-carboxyalkanoates. This process provides a pathway to new families of polysaccharide derivatives with drug delivery and other demanding commercial applications. Biomacromolecules, 2014, 15 (1), pp 177–187
Published: 11/14/2013   |   Inventor(s): Kevin Edgar, Xiangtao Meng, John Matson
Keywords(s):  
Category(s): Drug Delivery, Chemicals, Materials
Cellulose Ether Omega-Carboxyalkanoates for Drug Delivery and Coatings Applications
Novel polymers based on abundant, renewable cellulose, that are prepared by a highy practical process and that have outstanding organic solubility, compatibility with other polymers and with active small molecule species, and can be readily dispersed in water. They have outstanding promise in drug delivery (enhancing solubility of poorly soluble dr...
Published: 5/20/2013   |   Inventor(s): Kevin Edgar, Hale Cigdem Arca
Keywords(s):  
Category(s): Medical, Drug Delivery, Materials
Efficient Synthesis of Regioselectively Substituted Cellulose Esters
The ability to make cellulose esters with a high degree of control over the position of substitution is a very difficult problem in organic chemistry, polymer science, analytical chemistry, and materials science. The availability of efficient ways to make highly regioselectively substituted cellulose esters will enable structure-property studies th...
Published: 9/14/2012   |   Inventor(s): Kevin Edgar, Daiqiang Xu, Xueyan Zheng
Keywords(s): Biomaterials
Category(s): Process/Procedures, Chemicals
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