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Therapeutic Neutrophils for Cardiovascular Disease
THE CHALLENGE
Treating chronic inflammatory and cardiovascular diseases like atherosclerosis has proven difficult due to the lack of precision in current therapies. While these conditions are driven by complex immune responses, existing treatments rely heavily on broad, systemic anti-inflammatory drugs that often come with unwanted side effects and...
Published: 4/14/2025
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Inventor(s): Liwu Li, Shuo Geng
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics
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Neutrophil Subsets for the Treatment of Cancer
THE CHALLENGE
Developing a cancer immunotherapy platform that can effectively and safely leverage the complex role of neutrophils—an abundant, yet highly variable, type of innate immune cell continues to prove challenging. Unlike current therapies that primarily target the adaptive immune system, an approach that must navigate the dual nature...
Published: 4/14/2025
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Inventor(s): Liwu Li, Yao Zhang
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics
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Programmed Innate Leukocytes as Potent Therapeutic Agents to Treat Atherosclerosis and Stroke
This invention discloses a novel strategy to reprogram either allogenic or heterologous peripheral blood neutrophils and/or monocytes with a selective compound in vitro, into a homeostatic state that is conducive for healing of coronary heart disease and/or stroke. Reprogrammed monocytes and/or neutrophils can be used through i.v. injection into human...
Published: 1/31/2024
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Inventor(s): Liwu Li, Shuo Geng, Yao Zhang
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Enhanced Anti-Tumor Immune State
Challenge
Similar to vaccines, traditional immunotherapies target specific epitopes of cancerous cells. While several immunotherapies offer several benefits over other alternatives, immunotherapies are not very effective because of several reasons. Given that microbes/cells have similar epitopes and that tumors mutate, therapy may not work in all cases...
Published: 1/31/2024
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Inventor(s): Liwu Li, Yao Zhang, Christina Lee
Keywords(s):
Category(s): Technology Classifications > Biomedical
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