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Therapeutic Neutrophils for Cardiovascular Disease

THE CHALLENGE Treating chronic inflammatory and cardiovascular diseases like atherosclerosis has proven difficult due to the lack of precision in current therapies. While these conditions are driven by complex immune responses, existing treatments rely heavily on broad, systemic anti-inflammatory drugs that often come with unwanted side effects and...

Published: 4/14/2025 | Inventor(s): Liwu Li, Shuo Geng

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Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics

Programmed Innate Leukocytes as Potent Therapeutic Agents to Treat Atherosclerosis and Stroke

This invention discloses a novel strategy to reprogram either allogenic or heterologous peripheral blood neutrophils and/or monocytes with a selective compound in vitro, into a homeostatic state that is conducive for healing of coronary heart disease and/or stroke. Reprogrammed monocytes and/or neutrophils can be used through i.v. injection into human...

Published: 1/31/2024 | Inventor(s): Liwu Li, Shuo Geng, Yao Zhang

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Category(s): Technology Classifications > Biomedical