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Immune Activation of T Cells Using Electroporated Tumor Samples
THE CHALLENGE
A major challenge in advancing adoptive cell transfer immunotherapies is the difficulty of reliably producing large numbers of highly active tumor specific T cells in a way that is both cost efficient and scalable for real world clinical use. Current manufacturing workflows depend on lengthy cell culture steps, specialized facilities,...
Published: 8/20/2026
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Updated: 8/20/2026
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Inventor(s): Rafael Davalos, Scott Verbridge, Irving Allen, Nastaran Alinezhadbalalami
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Anti Angiopoietin-2 Antibody as a treatment for brain injury
THE CHALLENGE
Traumatic brain injury remains a major unmet need in healthcare because the most damaging consequences often arise after the initial trauma, when blood brain barrier breakdown, microvascular dysfunction, and neuroinflammation continue to worsen neurological outcomes. From a clinical and commercial perspective, healthcare providers currently...
Published: 8/6/2026
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Updated: 8/6/2026
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Inventor(s): Michelle Theus, Kylee Smith
Keywords(s):
Category(s): Technology Classifications > Pharmacology and Therapeutics, Technology Classifications > Biomedical
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Novel Implant Device for Plantar Plate Repair
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THE CHALLENGE
A major challenge in the current market for plantar plate repair is the lack of a reliable, minimally invasive solution that avoids serious postoperative complications while maintaining surgical effectiveness. Existing techniques often require suturing the plantar plate directly to the phalanx bone, which can lead to a problematic...
Published: 7/22/2026
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Updated: 7/22/2026
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Inventor(s): Demitria Poulos, Logan Dickinson, Skye Carlson, Zachary Kozar, Jennifer Wayne, Vincent Wang, John Clements
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Medical Devices
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Non-toxic System for Dual Release Intracranial Drug Delivery
THE CHALLENGE
Chronic subdural hematoma represents a significant unmet need in the neurosurgical and healthcare market, where current treatment pathways are both clinically and economically inefficient. Hospitals and providers rely heavily on surgical evacuation procedures that do not address the underlying inflammatory and angiogenic drivers of the...
Published: 6/9/2026
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Updated: 6/9/2026
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Inventor(s): Abby Whittington*, Betül Karanfil
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Compact MRI-Safe Tactile Stimulator with Precise Force Control
THE CHALLENGE
The MRI market is lacking reliable and MRI compatible tactile assessment technology that can deliver precise and measurable touch feedback for patients with neurological impairments. Existing solutions are either too bulky for routine clinical use or rely on components that disrupt MRI imaging, limiting their value for hospital research...
Published: 6/3/2026
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Updated: 6/3/2026
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Inventor(s): Netta Gurari, Nahid Kalantaryardebily, Suyi Li, Ardalan Kahak
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Engineering, Technology Classifications > Medical Devices
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BRAINWAVE: Beamforming Resonant Acoustics for INdividualized WAvefield VEctoring in skull-conformal ultrasound neuromodulation
THE CHALLENGE
The key challenge lies in translating advanced neuromodulation technologies into solutions that are both clinically precise and commercially scalable. Noninvasive approaches like Transcranial Magnetic Stimulation lack the spatial resolution needed to effectively reach deep brain regions, while invasive methods such as Deep Brain Stimulation...
Published: 6/3/2026
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Updated: 6/3/2026
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Inventor(s): Wynn Legon, Shima Shahab, Mihir Pewekar, Ceren Cengiz, Hrishikesh Kulkarni
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology
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Composition and Methods for Preparing Orally Bioavailable Guanidine Prodrugs
THE CHALLENGE
A major commercial hurdle in developing guanidine-based therapeutics lies in their poor oral bioavailability, which limits their effectiveness despite strong therapeutic potential. These compounds, while highly potent due to their ability to engage key molecular targets, struggle to reach the bloodstream when taken by mouth because of...
Published: 1/15/2026
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Updated: 1/15/2026
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Inventor(s): Webster Santos, Christopher Sibley, Kyle Dunnavant, Christopher Shrader, Ariel Burgio, Kevin Lynch, Yugesh Kharel
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Activation of BMP3 to Treat Pulmonary Hypertension
THE CHALLENGE
The major business challenge in addressing pulmonary arterial hypertension (PAH) lies in the urgent need for breakthrough therapies that go beyond symptom management to truly modify disease progression. Current drugs offer limited clinical benefit, are burdened by significant side effects, and fail to reverse the underlying biological...
Published: 6/17/2026
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Updated: 9/8/2025
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Inventor(s): Yassine Sassi, Aymen Halouani
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Droplet-Based Single-Cell Epigenomic Assay
THE CHALLENGE
A major challenge in single-cell DNA methylation profiling lies in the inefficiency and high cost of current methods, which rely on labor-intensive, plate- or tube-based workflows that are difficult to scale. These traditional approaches not only require multiple manual steps and expensive reagents but also suffer from significant DNA...
Published: 10/20/2025
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Updated: 8/14/2025
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Inventor(s): Chang Lu, Qiang Zhang
Keywords(s):
Category(s): Technology Classifications > Biotechnology, Technology Classifications > Biomedical
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Temporally Patterned Simulation Script/Algorithm/Software for the Treatment of Brain Injury, Neurodegenerative Diseases, and Psychiatric Disorders
THE CHALLENGE
The key challenge associated with stimulation based neurological treatment lies in bridging the gap between cutting-edge neuroscience and the current limitations of commercial neuromodulation devices, which largely rely on outdated, fixed-frequency stimulation protocols. Despite mounting evidence that the brain’s response to therapy...
Published: 10/31/2025
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Updated: 8/14/2025
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Inventor(s): Michael Friedlander, Quentin Fischer, Djanenkhodja Kalikulov, Carrie Williams, Philip Baldwin, Gonzalo Di Prisco
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Software
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