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High-Efficiency CRISPR Editing in Mammalian Zygotes
THE CHALLENGE
The major challenge in developing reliable gene editing solutions for livestock lies in delivering CRISPR reagents efficiently into mammalian zygotes without harming embryo viability, an issue that significantly limits scalability, consistency, and commercial viability. Traditional methods like microinjection are technically challenging,...
Published: 7/10/2025
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Inventor(s): Fernando Biase
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology
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Octopus-Mimetic Adhesives for Wet Surface Attachment
THE CHALLENGE
The challenge in creating effective underwater adhesion systems lies in bridging a critical gap between advanced materials science and real-world usability, especially for industries like marine robotics, offshore maintenance, and biomedical handling. Traditional solutions either bond too permanently, require ideal flat surfaces, consume...
Published: 7/3/2025
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Inventor(s): Michael Bartlett, Chanhong Lee
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Robotics
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Robotic Tail Used to Improve Performance and Stability of Mobile Robots
THE CHALLENGE
Natural and man-made disasters are becoming more and more commonplace. As these disasters increase in number, so does the need for, and risk to, first responders who search through rubble and rescue survivors. In response to these increased risks, legged mobile robots have emerged as a first response option as they can maneuver over...
Published: 6/30/2025
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Inventor(s): Pinhas Ben-Tzvi, Wael Saab, William Rone
Keywords(s):
Category(s): Technology Classifications > Engineering, Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Electronics, Technology Classifications > Medical Devices
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Genomic and Proteomic Biomarkers for Heifer Fertility
THE CHALLENGE
Fertility is a critical factor in livestock breeding, directly impacting the productivity and economic viability of beef and dairy operations. Each year, more than 750,000 beef heifers and 210,000 dairy heifers fail to produce calves despite multiple breeding attempts using artificial insemination or bull exposure. These sub-fertile or...
Published: 6/25/2025
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Inventor(s): Fernando Biase
Keywords(s):
Category(s): Technology Classifications > Biomedical
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SonicSurf Manipulator
THE CHALLENGE
Developing advanced contactless manipulation technologies lies in creating a solution that is not only technically effective but also scalable, affordable, and easy to integrate into real-world biomedical and chemical workflows. Current methods—like optical tweezers, magnetic actuators, and traditional acoustic systems—are...
Published: 6/25/2025
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Inventor(s): Zhenhua Tian, Teng Li, Jiali Li, Luyu Bo
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Chemicals/Materials, Technology Classifications > Engineering
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Washable SERS Fabrics via Micro-Imprinting
THE CHALLENGE
The major challenge in wearable SERS (Surface-Enhanced Raman Spectroscopy) sensors lies in bridging the gap between cutting-edge lab technology and real-world usability. While SERS offers powerful, label-free chemical detection at the molecular level, current fabrication methods rely on expensive clean-room processes, rigid substrates,...
Published: 6/25/2025
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Inventor(s): Aditya Garg, Wei Zhou
Keywords(s):
Category(s): Technology Classifications > Engineering, Technology Classifications > Biomedical
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Organoid-Based Maturation of Liver Stem Cells
THE CHALLENGE
The field of regenerative medicine and drug development urgently requires reliable in vitro liver models that accurately mimic primary human hepatocyte functions. Primary hepatocytes, though ideal for studying liver physiology, suffer from limited availability and high inter-donor variability. Induced pluripotent stem cells (iPSCs) hold...
Published: 6/25/2025
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Inventor(s): Padmavathy Rajagopalan, Neeti Gandhi
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Biomedical
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Fast Viral Detection via SERS and Machine Learning
THE CHALLENGE
The key challenge in developing effective virus detection tools for real-world environments lies in bridging the gap between laboratory-grade accuracy and field-ready usability. Current diagnostic methods like PCR and immunoassay are highly sensitive but depend on complex sample preparation, costly reagents, cold-chain logistics, and...
Published: 6/25/2025
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Inventor(s): Aditya Garg, Wei Zhou, Peter Vikesland, Linsey Marr, Nisha Duggal
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Engineering
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Serum-Free Media for Cell Culture
THE CHALLENGE
One of the biggest challenges facing the commercialization of cultivated meat is the heavy reliance on fetal bovine serum (FBS) in cell culture media—a component that is not only extremely expensive and ethically problematic, but also inconsistent due to its undefined and variable composition. FBS presents a major bottleneck to...
Published: 6/25/2025
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Inventor(s): Reza Ovissipour, Alexandrea Duscher, Inayat Batish
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology
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Therapeutic Neutrophils for Cardiovascular Disease
THE CHALLENGE
Treating chronic inflammatory and cardiovascular diseases like atherosclerosis has proven difficult due to the lack of precision in current therapies. While these conditions are driven by complex immune responses, existing treatments rely heavily on broad, systemic anti-inflammatory drugs that often come with unwanted side effects and...
Published: 6/25/2025
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Inventor(s): Liwu Li, Shuo Geng
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics
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