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Non-toxic System for Dual Release Intracranial Drug Delivery
THE CHALLENGE
Chronic subdural hematoma represents a significant unmet need in the neurosurgical and healthcare market, where current treatment pathways are both clinically and economically inefficient. Hospitals and providers rely heavily on surgical evacuation procedures that do not address the underlying inflammatory and angiogenic drivers of the...
Published: 6/9/2026
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Updated: 6/9/2026
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Inventor(s): Abby Whittington*, Betül Karanfil
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Compact MRI-Safe Tactile Stimulator with Precise Force Control
THE CHALLENGE
The MRI market is lacking reliable and MRI compatible tactile assessment technology that can deliver precise and measurable touch feedback for patients with neurological impairments. Existing solutions are either too bulky for routine clinical use or rely on components that disrupt MRI imaging, limiting their value for hospital research...
Published: 6/3/2026
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Updated: 6/3/2026
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Inventor(s): Netta Gurari, Nahid Kalantaryardebily, Suyi Li, Ardalan Kahak
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Engineering, Technology Classifications > Medical Devices
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BRAINWAVE: Beamforming Resonant Acoustics for INdividualized WAvefield VEctoring in skull-conformal ultrasound neuromodulation
THE CHALLENGE
The key challenge lies in translating advanced neuromodulation technologies into solutions that are both clinically precise and commercially scalable. Noninvasive approaches like Transcranial Magnetic Stimulation lack the spatial resolution needed to effectively reach deep brain regions, while invasive methods such as Deep Brain Stimulation...
Published: 6/3/2026
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Updated: 6/3/2026
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Inventor(s): Wynn Legon, Shima Shahab, Mihir Pewekar, Ceren Cengiz, Hrishikesh Kulkarni
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology
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Composition and Methods for Preparing Orally Bioavailable Guanidine Prodrugs
THE CHALLENGE
A major commercial hurdle in developing guanidine-based therapeutics lies in their poor oral bioavailability, which limits their effectiveness despite strong therapeutic potential. These compounds, while highly potent due to their ability to engage key molecular targets, struggle to reach the bloodstream when taken by mouth because of...
Published: 1/15/2026
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Updated: 1/15/2026
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Inventor(s): Webster Santos, Christopher Sibley, Kyle Dunnavant, Christopher Shrader, Ariel Burgio, Kevin Lynch, Yugesh Kharel
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Activation of BMP3 to Treat Pulmonary Hypertension
THE CHALLENGE
The major business challenge in addressing pulmonary arterial hypertension (PAH) lies in the urgent need for breakthrough therapies that go beyond symptom management to truly modify disease progression. Current drugs offer limited clinical benefit, are burdened by significant side effects, and fail to reverse the underlying biological...
Published: 6/17/2026
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Updated: 9/8/2025
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Inventor(s): Yassine Sassi, Aymen Halouani
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Droplet-Based Single-Cell Epigenomic Assay
THE CHALLENGE
A major challenge in single-cell DNA methylation profiling lies in the inefficiency and high cost of current methods, which rely on labor-intensive, plate- or tube-based workflows that are difficult to scale. These traditional approaches not only require multiple manual steps and expensive reagents but also suffer from significant DNA...
Published: 10/20/2025
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Updated: 8/14/2025
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Inventor(s): Chang Lu, Qiang Zhang
Keywords(s):
Category(s): Technology Classifications > Biotechnology, Technology Classifications > Biomedical
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Temporally Patterned Simulation Script/Algorithm/Software for the Treatment of Brain Injury, Neurodegenerative Diseases, and Psychiatric Disorders
THE CHALLENGE
The key challenge associated with stimulation based neurological treatment lies in bridging the gap between cutting-edge neuroscience and the current limitations of commercial neuromodulation devices, which largely rely on outdated, fixed-frequency stimulation protocols. Despite mounting evidence that the brain’s response to therapy...
Published: 10/31/2025
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Updated: 8/14/2025
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Inventor(s): Michael Friedlander, Quentin Fischer, Djanenkhodja Kalikulov, Carrie Williams, Philip Baldwin, Gonzalo Di Prisco
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Software
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High-Efficiency CRISPR Editing in Mammalian Zygotes
THE CHALLENGE
The major challenge in developing reliable gene editing solutions for livestock lies in delivering CRISPR reagents efficiently into mammalian zygotes without harming embryo viability, an issue that significantly limits scalability, consistency, and commercial viability. Traditional methods like microinjection are technically challenging,...
Published: 10/24/2025
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Updated: 7/10/2025
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Inventor(s): Fernando Biase
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology
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Octopus-Mimetic Adhesives for Wet Surface Attachment
THE CHALLENGE
The challenge in creating effective underwater adhesion systems lies in bridging a critical gap between advanced materials science and real-world usability, especially for industries like marine robotics, offshore maintenance, and biomedical handling. Traditional solutions either bond too permanently, require ideal flat surfaces, consume...
Published: 3/2/2026
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Updated: 7/3/2025
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Inventor(s): Michael Bartlett, Chanhong Lee
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Robotics
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Robotic Tail Used to Improve Performance and Stability of Mobile Robots
THE CHALLENGE
Natural and man-made disasters are becoming more and more commonplace. As these disasters increase in number, so does the need for, and risk to, first responders who search through rubble and rescue survivors. In response to these increased risks, legged mobile robots have emerged as a first response option as they can maneuver over...
Published: 6/30/2025
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Updated: 6/30/2025
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Inventor(s): Pinhas Ben-Tzvi, Wael Saab, William Rone
Keywords(s):
Category(s): Technology Classifications > Engineering, Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Electronics, Technology Classifications > Medical Devices
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