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Chip-based Nano-optoelectrodes for Optical Voltage Sensing
THE CHALLENGE
The challenge in developing reliable, scalable optical voltage sensors lies at the intersection of technical complexity and commercial viability. Current solutions—ranging from fluorescent dyes to random plasmonic nanostructures—face critical limitations: they either require invasive labeling, suffer from photobleaching,...
Published: 7/3/2025
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Inventor(s): Yuming Zhao, Chuan Xiao, Wei Zhou
Keywords(s):
Category(s): Technology Classifications > Electronics
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Micro-/nano-optoelectrode Arrays by Hierarchical Modular Design
THE CHALLENGE
The growing demand for real-time monitoring of complex biological systems—like brain networks, stem-cell growth, and mini-organs—has exposed a major gap in the market: the lack of scalable, integrated sensor platforms that can simultaneously capture both electrical signals and chemical changes in 3D environments. Current...
Published: 7/3/2025
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Inventor(s): Elieser Mejia, Wei Zhou
Keywords(s):
Category(s): Technology Classifications > Biotechnology
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Washable SERS Fabrics via Micro-Imprinting
THE CHALLENGE
The major challenge in wearable SERS (Surface-Enhanced Raman Spectroscopy) sensors lies in bridging the gap between cutting-edge lab technology and real-world usability. While SERS offers powerful, label-free chemical detection at the molecular level, current fabrication methods rely on expensive clean-room processes, rigid substrates,...
Published: 6/25/2025
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Inventor(s): Aditya Garg, Wei Zhou
Keywords(s):
Category(s): Technology Classifications > Engineering, Technology Classifications > Biomedical
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Fast Viral Detection via SERS and Machine Learning
THE CHALLENGE
The key challenge in developing effective virus detection tools for real-world environments lies in bridging the gap between laboratory-grade accuracy and field-ready usability. Current diagnostic methods like PCR and immunoassay are highly sensitive but depend on complex sample preparation, costly reagents, cold-chain logistics, and...
Published: 6/25/2025
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Inventor(s): Aditya Garg, Wei Zhou, Peter Vikesland, Linsey Marr, Nisha Duggal
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Engineering
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Chip-integrated Nanolaminate Nano-optoelectrode Arrays for Interfacial Electrochemical Reaction Monitoring
THE CHALLENGE:
In the field of electrochemistry, understanding the dynamics of interfacial reactions is crucial for advancements in areas such as electrocatalysis, biosensing, and energy conversion. Real-time monitoring of these reactions allows scientists to gain insights into mechanisms that drive these processes. Accurate and detailed analysis of...
Published: 4/2/2025
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Inventor(s): Yuming Zhao, Chuan Xiao, Wei Zhou
Keywords(s):
Category(s): Technology Classifications > Chemicals/Materials
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Transparent NanoplasmonicMeshes for
Bio-interfaced Multimodal Biochemical Sensing
THE CHALLENGE
For multicellular systems such as microbial biofilms and tumors it is essential to capture the holistic system-level spatiotemporal picture. This allows for the understanding of complex and dynamically evolving biological activities to determine effective therapeutic intervention methods. Currently, standard bioanalysis methods do not...
Published: 6/25/2025
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Inventor(s): Aditya Garg, Wei Zhou, Elieser Mejia
Keywords(s):
Category(s): Technology Classifications > Chemicals/Materials, Technology Classifications, Technology Classifications > Biotechnology
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Drug Dosage Testing using Surface-enhanced
Raman Spectroscopy
THE CHALLENGE
Plasmonic nanostructures have enabled label-free surfaceenhanced Raman spectroscopy (SERS) to emerge as a rapid nondestructive molecular fingerprint characterization technique for complex biological samples. However, label-free SERs bioanalysis faces significant challenges in reliability and reproducibility due to local optical field...
Published: 6/26/2025
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Inventor(s): Wei Zhou, Wonil Nam
Keywords(s):
Category(s): Technology Classifications > Biotechnology
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Multiresonant Plasmonic Meshes for Bio-interfaced
Sensing and Actuation
THE CHALLENGE
Mesh plasmonic devices have the potential to combine the biocompatibility of polymeric meshes with the capabilities of plasmonic nanostructures to enhance nanoscale light-matter interactions for bio-interfaced optical sensing and actuation. However, scalable integration of uniformly structured plasmonic hotspot arrays with polymeric...
Published: 6/25/2025
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Inventor(s): Aditya Garg, Wei Zhou, Peter Vikesland
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications, Technology Classifications > Biotechnology, Technology Classifications > Chemicals/Materials
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