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Formulation of Iron Oxide Nanoparticle Suspensions for FUS/MRI Applications
Focused ultrasound combined with magnetic resonance imaging (FUS/MRI) is a promising approach for noninvasive therapy that requires precise imaging of tissue using MRI to guide the FUS process. The MRI suffers from interference from water baths commonly used to transmit the focused ultrasound waves from a transmitter to the tissue. In this work, iron...
Published: 12/20/2023   |   Inventor(s): Richey Davis, Austin Fergusson, Eli Vlaisavljevich, Connor Edsall, Craig Meyer, Steven Allen
Keywords(s):  
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology
An Assistive Robotic Exoskeleton Glove Designed for Patients with Brachial Plexus Injuries
THE CHALLENGE Exoskeleton gloves have proven to be invaluable in post-surgery therapy for patients with Brachial Plexus Injuries, countering hand muscle atrophy through controlled and assisted movements. While many rehab gloves target stroke recovery, they lack the desired Human-Machine Interface and struggle to find the right balance between performance...
Published: 11/21/2023   |   Inventor(s): Pinhas Ben-Tzvi, Bijo Sebastian, Eric Refour
Keywords(s):  
Category(s): Technology Classifications > Engineering, Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Electronics, Technology Classifications > Medical Devices, Technology Classifications > Robotics
Transparent NanoplasmonicMeshes for Bio-interfaced Multimodal Biochemical Sensing
THE CHALLENGE For multicellular systems such as microbial biofilms and tumors it is essential to capture the holistic system-level spatiotemporal picture. This allows for the understanding of complex and dynamically evolving biological activities to determine effective therapeutic intervention methods. Currently, standard bioanalysis methods do not...
Published: 2/1/2024   |   Inventor(s): Aditya Garg, Wei Zhou, Elieser Mejia
Keywords(s):  
Category(s): Technology Classifications > Chemicals/Materials, Technology Classifications, Technology Classifications > Biotechnology
Nanoparticle-based Nicotine Nanovaccine
THE CHALLENGE: Tobacco smoking is one of the largest public health threats the world has ever faced and results in over seven million deaths annually world wide. Smoking cessation is a difficult and largely unsuccessful undertaking; only 3-5% of unassisted smokers are able to remain abstinent for more than six months, and the use of pharmacological...
Published: 11/7/2023   |   Inventor(s): Chenming (mike) Zhang, Zongmin Zhao
Keywords(s):  
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics
New process for selective polysaccharide derivative oxidation
THE CHALLENGE Aqueous solubility and controllable release are essential for bioactive compounds. In the case of oral drug delivery, poor aqueous solubility of a drug can lead to low bioavailability. For poorly bioavailable drugs, higher doses are required to achieve a therapeutic concentration in systemic circulation. This can in turn have negative...
Published: 5/30/2024   |   Inventor(s): Kevin Edgar, Brittany Nichols, Ann Norris, Laura Mosquera-Giraldo, Lynne Taylor, Junyi Chen, Charles Frazier, Benjamin Adams
Keywords(s):  
Category(s): Technology Classifications > Chemicals/Materials, Technology Classifications > Biotechnology, Technology Classifications, Technology Classifications > Biomedical, Technology Classifications > Pharmacology and Therapeutics
Drug Dosage Testing using Surface-enhanced Raman Spectroscopy
THE CHALLENGE Plasmonic nanostructures have enabled label-free surfaceenhanced Raman spectroscopy (SERS) to emerge as a rapid nondestructive molecular fingerprint characterization technique for complex biological samples. However, label-free SERs bioanalysis faces significant challenges in reliability and reproducibility due to local optical field...
Published: 12/20/2023   |   Inventor(s): Wei Zhou, Wonil Nam
Keywords(s):  
Category(s): Technology Classifications > Biotechnology
Multiresonant Plasmonic Meshes for Bio-interfaced Sensing and Actuation
THE CHALLENGE Mesh plasmonic devices have the potential to combine the biocompatibility of polymeric meshes with the capabilities of plasmonic nanostructures to enhance nanoscale light-matter interactions for bio-interfaced optical sensing and actuation. However, scalable integration of uniformly structured plasmonic hotspot arrays with polymeric meshes...
Published: 6/20/2024   |   Inventor(s): Aditya Garg, Wei Zhou, Peter Vikesland
Keywords(s):  
Category(s): Technology Classifications > Biomedical, Technology Classifications, Technology Classifications > Biotechnology, Technology Classifications > Chemicals/Materials
Novel Production Method of Stink Bug Pheromone for Crop Protection
THE CHALLENGE In integrated pest management, synthetic pheromones are often deployed in traps or with trap crops to lure insects away from commercial crops. Currently these pheromones are chemically synthesized and applied to trap crops. This form of production has limited sustainability and there are difficulties with high yield production. Therefore,...
Published: 11/1/2023   |   Inventor(s): Dorothea Tholl, Jason Lancaster
Keywords(s):  
Category(s): Technology Classifications > Agriculture, Technology Classifications, Technology Classifications > Biotechnology
Therapeutic Applications to Modulate BRCA1 in Cancer Cells
Physical properties of BRCA1 make in amenable to unconventional treatment options that interfere with or modify the protein to control its function in cells. In the case of healthy individuals therapeutic applications to stabilize the BRCA1 protein may be beneficial as a preventative measure -- either before or following primary interventions. In the...
Published: 1/31/2024   |   Inventor(s): Deborah Kelly, Yanping Liang, William Dearnaley
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Biomedical, Technology Classifications > Biotechnology
3D Printable Multifunctional Fibers
THE CHALLENGE 3D printing has enabled the customized production of many objects and devices, but that technology currently only creates passive units. THE SOLUTION Researchers at Virginia Tech have developed a coaxial micro-extrusion technique that enables us to take advantage of triboelectric energy generation and custom build sensors to fit anywhere....
Published: 11/6/2023   |   Inventor(s): Blake Johnson, Yuxin Tong, John Robertson, Xiaoting Jia, Ziang Feng
Keywords(s):  
Category(s): Technology Classifications > Engineering, Technology Classifications > Biotechnology, Technology Classifications > Biomedical, Technology Classifications > Energy, Technology Classifications > Additive Manufacturing, Technology Classifications > Electronics, Technology Classifications > Medical Devices