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High-Efficiency CRISPR Editing in Mammalian Zygotes
THE CHALLENGE
The major challenge in developing reliable gene editing solutions for livestock lies in delivering CRISPR reagents efficiently into mammalian zygotes without harming embryo viability, an issue that significantly limits scalability, consistency, and commercial viability. Traditional methods like microinjection are technically challenging,...
Published: 7/10/2025
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Inventor(s): Fernando Biase
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology
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Octopus-Mimetic Adhesives for Wet Surface Attachment
THE CHALLENGE
The challenge in creating effective underwater adhesion systems lies in bridging a critical gap between advanced materials science and real-world usability, especially for industries like marine robotics, offshore maintenance, and biomedical handling. Traditional solutions either bond too permanently, require ideal flat surfaces, consume...
Published: 7/3/2025
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Inventor(s): Michael Bartlett, Chanhong Lee
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Robotics
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Micro-/nano-optoelectrode Arrays by Hierarchical Modular Design
THE CHALLENGE
The growing demand for real-time monitoring of complex biological systems—like brain networks, stem-cell growth, and mini-organs—has exposed a major gap in the market: the lack of scalable, integrated sensor platforms that can simultaneously capture both electrical signals and chemical changes in 3D environments. Current...
Published: 7/3/2025
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Inventor(s): Elieser Mejia, Wei Zhou
Keywords(s):
Category(s): Technology Classifications > Biotechnology
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Antimicrobial Photocatalytic Films for Packaging and Surfaces
THE CHALLENGE
A major business challenge in the food packaging industry lies in developing cost-effective, scalable antimicrobial solutions that meet both regulatory standards and consumer expectations for safety and sustainability. While existing technologies like synthetic preservatives, UV-activated coatings, and metal nanoparticles offer short-term...
Published: 7/3/2025
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Inventor(s): Haibo Huang, Danmeng Shuai, Young-Teck Kim, Jian Wu, Andrea Johnson
Keywords(s):
Category(s): Technology Classifications > Biotechnology, Technology Classifications > Consumer Products, Technology Classifications > Electronics
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Robotic Tail Used to Improve Performance and Stability of Mobile Robots
THE CHALLENGE
Natural and man-made disasters are becoming more and more commonplace. As these disasters increase in number, so does the need for, and risk to, first responders who search through rubble and rescue survivors. In response to these increased risks, legged mobile robots have emerged as a first response option as they can maneuver over...
Published: 6/30/2025
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Inventor(s): Pinhas Ben-Tzvi, Wael Saab, William Rone
Keywords(s):
Category(s): Technology Classifications > Engineering, Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Electronics, Technology Classifications > Medical Devices
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Highly Sensitive 3D Sensors for Prevention of Hypocalcemia in Dairy Cows
THE CHALLENGE
Hypocalcemia, colloquially known as Milk Fever, is a common metabolic disorder caused by severe calcium deficiency most prevalent in dairy cows. This disorder has clinical and subclinical levels of severity, the latter often going undetected due to lack of symptoms. Without treatment, up to 60-80% of cases result in death. Further, milk...
Published: 6/25/2025
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Inventor(s): Azahar Ali, Matin Ataei Kachouei
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Agriculture, Technology Classifications > Biotechnology, Technology Classifications > Chemicals/Materials, Technology Classifications > Electronics, Technology Classifications > Veterinary Technologies
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Grazing Forage Monitoring with Smart Animal Wearables
THE CHALLENGE
Effective livestock management for grazing animals like horses hinges on accurately monitoring feeding behavior and forage quality to optimize animal health and productivity. Traditional methods, which often involve manual observation, are labor-intensive, time-consuming, and susceptible to error, thereby providing only fragmented data...
Published: 6/25/2025
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Inventor(s): Robin White
Keywords(s):
Category(s): Technology Classifications > Veterinary Technologies, Technology Classifications > Electronics, Technology Classifications > Biotechnology
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Serum-Free Media for Cell Culture
THE CHALLENGE
One of the biggest challenges facing the commercialization of cultivated meat is the heavy reliance on fetal bovine serum (FBS) in cell culture media—a component that is not only extremely expensive and ethically problematic, but also inconsistent due to its undefined and variable composition. FBS presents a major bottleneck to...
Published: 6/25/2025
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Inventor(s): Reza Ovissipour, Alexandrea Duscher, Inayat Batish
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology
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Therapeutic Neutrophils for Cardiovascular Disease
THE CHALLENGE
Treating chronic inflammatory and cardiovascular diseases like atherosclerosis has proven difficult due to the lack of precision in current therapies. While these conditions are driven by complex immune responses, existing treatments rely heavily on broad, systemic anti-inflammatory drugs that often come with unwanted side effects and...
Published: 6/25/2025
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Inventor(s): Liwu Li, Shuo Geng
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics
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Neutrophil Subsets for the Treatment of Cancer
THE CHALLENGE
Developing a cancer immunotherapy platform that can effectively and safely leverage the complex role of neutrophils—an abundant, yet highly variable, type of innate immune cell continues to prove challenging. Unlike current therapies that primarily target the adaptive immune system, an approach that must navigate the dual nature...
Published: 6/25/2025
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Inventor(s): Liwu Li, Yao Zhang
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics
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