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Therapeutic Neutrophils for Cardiovascular Disease
THE CHALLENGE
Treating chronic inflammatory and cardiovascular diseases like atherosclerosis has proven difficult due to the lack of precision in current therapies. While these conditions are driven by complex immune responses, existing treatments rely heavily on broad, systemic anti-inflammatory drugs that often come with unwanted side effects and...
Published: 4/14/2025
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Inventor(s): Liwu Li, Shuo Geng
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics
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Neutrophil Subsets for the Treatment of Cancer
THE CHALLENGE
Developing a cancer immunotherapy platform that can effectively and safely leverage the complex role of neutrophils—an abundant, yet highly variable, type of innate immune cell continues to prove challenging. Unlike current therapies that primarily target the adaptive immune system, an approach that must navigate the dual nature...
Published: 4/14/2025
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Inventor(s): Liwu Li, Yao Zhang
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics
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Infant OPM-MEG Helmet for Measuring Brain Activity
THE CHALLENGE:
Understanding infant brain development is crucial for early detection of neurological disorders and for advancing research in cognitive and sensory development. Neuroimaging technologies enable scientists and clinicians to monitor brain activity, providing insights into how infants' brains respond to various stimuli and interact...
Published: 4/25/2025
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Inventor(s): Brittany Howell, Megan Evans, Claudia Carreno, Jamie Holt, Saket Bikmal, Mateo McDermott
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Pharmacology and Therapeutics
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Nanoparticle-based Nicotine Nanovaccine
THE CHALLENGE:
Tobacco smoking is one of the largest public health threats the world has ever faced and results in over seven million deaths annually world wide. Smoking cessation is a difficult and largely unsuccessful undertaking; only 3-5% of unassisted smokers are able to remain abstinent for more than six months, and the use of pharmacological...
Published: 7/15/2024
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Inventor(s): Chenming (mike) Zhang, Zongmin Zhao
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics
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Novel Electrolyte Formulation to Enhance Cardiac
Function
THE CHALLENGE
There are over 350,000 out-of-hospital cardiac arrests each year, with each patient seen by EMS receiving a liter of crystalloid solution (usually 0.9% saline). Only about two thirds of those patients have a pulse return; the remainder die from the condition called pulseless electrical activity (PEA) or electromechanical disassociation....
Published: 7/15/2024
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Inventor(s): Steven Poelzing, David King
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Pharmacology and Therapeutics
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New process for selective polysaccharide derivative oxidation
THE CHALLENGE
Aqueous solubility and controllable release are essential for bioactive compounds. In the case of oral drug delivery, poor aqueous solubility of a drug can lead to low bioavailability. For poorly bioavailable drugs, higher doses are required to achieve a therapeutic concentration in systemic circulation. This can in turn have negative...
Published: 5/30/2024
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Inventor(s): Kevin Edgar, Brittany Nichols, Ann Norris, Laura Mosquera-Giraldo, Lynne Taylor, Junyi Chen, Charles Frazier, Benjamin Adams
Keywords(s):
Category(s): Technology Classifications > Chemicals/Materials, Technology Classifications > Biotechnology, Technology Classifications, Technology Classifications > Biomedical, Technology Classifications > Pharmacology and Therapeutics
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Residual Glioblastoma and Glioma Cell Capture
THE CHALLENGE
Physical removal of tumors in most cases cannot eradicate all the cancerous cells in the affected area. The cells that are left behind are known as residual tumor cells due to their inability to be removed. Some of these residual cells are also resistant to chemotherapy which make them particularly threatening as this is the primary method...
Published: 1/31/2024
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Inventor(s): Zerin Khan, Scott Verbridge, Timothy Long, Eli Vlaisavljevich
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications, Technology Classifications > Pharmacology and Therapeutics
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Fiber Array for Optical Imaging and Therapeutics
This technology is a biomedical device that allows increased light penetration in skin and can substantially improve a variety of light-based therapeutic and diagnostic procedures. The device has an array of optically transparent fibers (either nano- or microscale in diameter) which are guided into a patient's skin by the simultaneous application...
Published: 10/25/2023
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Inventor(s): Christopher Rylander, Thomas Campbell, Ge Wang, Yong Xu, Mehmet Kosoglu
Keywords(s): Medical/Imaging
Category(s): Technology Classifications > Biomedical, Technology Classifications > Pharmacology and Therapeutics
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Personalized Medicine Using Additive Manufacturing
THE CHALLENGE
A major problem posed by the pharmaceutical industry is giving effective dosages while not giving excessive amounts of a particular drug. An estimated 80% of side effects in humans and animals are a direct result of inaccurate dosing because varying weights in patients. Additive manufacturing has emerged as a very promising method to...
Published: 4/9/2025
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Inventor(s): Emily Wilts, Timothy Long, Christopher Williams, Da Ma
Keywords(s):
Category(s): Technology Classifications > Additive Manufacturing, Technology Classifications > Biomedical, Technology Classifications > Chemicals/Materials, Technology Classifications > Pharmacology and Therapeutics
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